Research

 

 

People

 

 

Publications

 

 

Software

 

 

Links

 

 

 

 

Publications

 

2008, 2007, 2006, 2005, 2004, 2003, 2001, 2000

 

Selected

 

Cheng Li (2008) Automating dChip: toward reproducible sharing of microarray data analysis. BMC Bioinformatics. 9:231. (PubMed)

 

Cheng Li, Rameen Beroukhim, Barbara A. Weir, Wendy Winckler, Levi A. Garraway, William R. Sellers, Matthew Meyerson (2008) Major copy proportion analysis of tumor samples using SNP arrays. BMC Bioinformatics. 9:204. (PubMed)

 

W. Evan Johnson, Cheng Li, Ariel Rabinovic (2007) Adjusting batch effects in microarray expression data using Empirical Bayes methods. Biostatistics. 8(1):118-127 (PubMed, Software)

 

Beroukhim R, Lin M, Park Y, Hao K, Zhao X, Garraway LA, Fox EA, Hochberg EP, Mellinghoff IK, Hofer MD, Descazeaud A, Rubin MA, Meyerson M, Wong WH, Sellers WR*, Li C* (2006) Inferring Loss-of-Heterozygosity From Tumor-only Samples Using High-Density Oligonucleotide SNP Arrays. PLoS Computational Biology. 2(5): e41. (PubMed, dChip usage, Joint first authors)

 

Igor Leykin, Ke Hao, Junsheng Cheng, Nicole Meyer, Martin R Pollak, Richard JH Smith, Wing Hung Wong, Carsten Rosenow*, Cheng Li* (2005) Comparative linkage analysis and visualization of high-density oligonucleotide SNP array data. BMC Genetics. 6:7. (PubMed, Software, dChip usage)

 

Ming Lin, Lee-Jen Wei, William R. Sellers, Marshall Lieberfarb, Wing Hung Wong*, and Cheng Li* (2004) dChipSNP: Significance Curve and Clustering of SNP-Array-Based Loss-of-Heterozygosity Data. Bioinformatics. 20: 1233-1240. (PubMed, Journal, Data and Software, dChip usage)

 

Sheng Zhong, Cheng Li* and Wing Hung Wong* (2003) ChipInfo: Software for Extracting Gene Annotation and Gene Ontology Information for Microarray Analysis. Nucleic Acids Research. Vol. 31, 3483-3486. (PubMed, Journal, Software, dChip usage)

 

Cheng Li and Wing Hung Wong (2003) DNA-Chip Analyzer (dChip). In The analysis of gene expression data: methods and software. Edited by G Parmigiani, ES Garrett, R Irizarry and SL Zeger. Springer, New York. 120-141. (Book site)

 

Cheng Li and Wing Hung Wong (2001b) Model-based analysis of oligonucleotide arrays: model validation, design issues and standard error application, Genome Biology 2(8): research0032.1-0032.11 (PubMed)

 

Cheng Li and Wing Hung Wong (2001a) Model-based analysis of oligonucleotide arrays: Expression index computation and outlier detection, Proc. Natl. Acad. Sci. Vol. 98, 31-36. (PubMed, Journal)

 

*Joint corresponding authors

 

2008 (Top)

 

Cheng Li, Samir Amin (2008) Analysis of cancer genome alterations using single nucleotide polymorphism (SNP) microarrays. In New developments in biostatistics and bioinformatics. Edited by Jianqing Fan, Xihong Lin and Jun Liu. In press.

 

2007 (Top)

 

Yuhyun Park, Sean R. Downing, Dohyun Kim, William C. Hahn, Cheng Li, Philip W. Kantoff, L.J. Wei (2007) Simultaneous and exact interval estimates for the contrast of two groups based on an extremely high dimensional variable: Application to Mass Spec data. Bioinformatics. 23(12):1451-1458. (PubMed, Joint first authors)

 

Vallat LD, Park Y, Li C, Gribben JG. (2007) Temporal genetic program following B-cell receptor cross-linking: altered balance between proliferation and death in healthy and malignant B cells. Blood. 109(9):3989-97. (PubMed)

 

George RE, Attiyeh EF, Li S, Moreau LA, Neuberg D, Li C, Fox EA, Meyerson M, Diller L, Fortina P, Look AT, Maris JM (2007) Genome-Wide Analysis of Neuroblastomas using High-Density Single Nucleotide Polymorphism Arrays. PLoS ONE 2(2): e255. (PubMed)

 

Bae J, Mitsiades C, Tai YT, Bertheau R, Shammas M, Batchu RB, Li C, Catley L, Prabhala R, Anderson KC, Munshi NC. (2007) Phenotypic and functional effects of heat shock protein 90 inhibition on dendritic cell. J Immunol. 178(12):7730-7. (PubMed)

 

Wong YF, Cheung TH, Lo KW, Yim SF, Siu NS, Chan SC, Ho TW, Wong KW, Yu MY, Wang VW, Li C, Gardner GJ, Bonome T, Johnson WB, Smith DI, Chung TK, Birrer MJ. (2007) Identification of molecular markers and signaling pathway in endometrial cancer in Hong Kong Chinese women by genome-wide gene expression profiling. Oncogene. 26:1971-82. (PubMed)

 

2006 (Top)

 

BA Walker, PE Leone, MW Jenner, C Li, D Gonzalez, DC Johnson, FM Ross, FE Davies, GJ Morgan (2006) Integration of global SNP-based mapping and expression arrays reveals key regions, mechanisms, and genes important in the pathogenesis of multiple myeloma. Blood 108: 1733-1743. (PubMed)

 

Juszczynski P, Kutok JL, Li C, Mitra J, Aguiar RC, Shipp MA. (2006) BAL1 and BBAP are regulated by a gamma interferon-responsive bidirectional promoter and are overexpressed in diffuse large B-cell lymphomas with a prominent inflammatory infiltrate. Mol Cell Biol. 26(14):5348-59. (PubMed)

 

Moran JL, Bolton AD, Tran PV, Brown A, Dwyer ND, Manning DK, Bjork BC, Li C, Montgomery K, Siepka SM, Vitaterna MH, Takahashi JS, Wiltshire T, Kwiatkowski DJ, Kucherlapati R, Beier DR. (2006) Utilization of a whole genome SNP panel for efficient genetic mapping in the mouse. Genome Res. 16:436-440. (PubMed)

 

2005 (Top)

 

Garraway LA, Widlund HR, Rubin MA, Getz G, Berger AJ, Ramaswamy S, Beroukhim R, Milner DA, Granter SR, Du J, Lee C, Wagner SN, Li C, Golub TR, Rimm DL, Meyerson ML, Fisher DE, Sellers WR (2005) Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma. Nature. 436(7047):117-22. (PubMed, GEO data)

 

X Zhao, BA Weir, T LaFramboise, M Lin, R Beroukhim, L Garraway, J Beheshti, JC Lee, K Naoki, WG Richards, D Sugarbaker, F Chen, MA Rubin, PA Jänne, L Girard, J Minna, D Christiani, C Li, WR Sellers, M Meyerson (2005) Homozygous Deletions and Chromosome Amplifications in Human Lung Carcinomas Revealed by Single Nucleotide Polymorphism Array Analysis. Cancer Research. 65: 5561-5570. (Journal, Data, News)

 

Wang V, Li C, Lin M, Welch W, Bell D, Wong YF, Berkowitz R, Mok SC, Bandera CA (2005) Ovarian cancer is a heterogeneous disease. Cancer Genet Cytogene. 161(2):170-3.

 

Goodison S, Yuan J, Sloan D, Kim R, Li C, Popescu NC, Urquidi V (2005) The RhoGAP protein DLC-1 functions as a metastasis suppressor in breast cancer cells. Cancer Res. 65(14):6042-53. (Abstract)

 

PLM Dahia, K Hao, J Rogus, C Colin, MAG Pujana, K Ross, D Magoffin, N Aronin, A Cascon, CY Hayashida, C Li, SPA Toledo, CD Stiles, and for the Familial Pheochromocytoma Consortium (2005) Novel Pheochromocytoma Susceptibility Loci Identified by Integrative Genomics. Cancer Res 65: 9651-9658. (Abstract)

 

T LaFramboise, BA Weir, X Zhao, R Beroukhim, C Li, D Harrington, WR Sellers, M Meyerson (2005) Allele-Specific Amplification in Cancer Revealed by SNP Array Analysis. PLoS Comput Biol 1(6): e65. (Abstract, R package)

 

PLM Dahia, KN Ross, ME Wright, CY Hayashida, S Santagata, M Barontini, AL Kung, G Sanso, JF Powers, AS Tischler, R Hodin, S Heitritter, F Moore, R Dluhy, JA Sosa, IT Ocal, DE Benn, DJ Marsh, BG Robinson, K Schneider, J Garber, SM Arum, M Korbonits, A Grossman, P Pigny, SPA Toledo, V Nosé, C Li, CD Stiles (2005) A HIF1α Regulatory Loop Links Hypoxia and Mitochondrial Signals in Pheochromocytomas. PLoS Genet. 1(1): e8.

 

Tang D, Khaleque MA, Jones EL, Theriault JR, Li C, Wong WH, Stevenson MA, Calderwood SK (2005) Expression of heat shock proteins and heat shock protein messenger ribonucleic acid in human prostate carcinoma in vitro and in tumors in vivo. Cell Stress Chaperones. 10(1):46-58. (Abstract)

 

Wang Z, Neuburg D, Li C, Su L, Kim JY, Chen JC, Christiani DC (2005) Global gene expression profiling in whole-blood samples from individuals exposed to metal fumes. Environ Health Perspect. 113(2):233-41.

 

2004 (Top)

 

Lu T, Pan Y, Kao SY, Li C, Kohane I, Chan J, Yankner BA (2004) Gene regulation and DNA damage in the ageing human brain. Nature. 429, 883–891. (PubMed, Supplement, GEO data, dChip usage)

 

X Zhao, C Li, JG Paez, K Chin, PA Jänne, TH Chen, L Girard, J Minna, D Christiani, C Leo, JW Gray, WR Sellers, M Meyerson (2004) An integrated view of copy number and allelic alterations in the cancer genome using single nucleotide polymorphism arrays. Cancer Research. 64:3060-3071. (Abstract, Data)

 

Janne PA, Li C, Zhao X, Girard L, Chen TH, Minna J, Christiani DC, Johnson BE, Meyerson M (2004) High-resolution single-nucleotide polymorphism array and clustering analysis of loss of heterozygosity in human lung cancer cell lines. Oncogene. 23(15):2716-26. (Abstract; dChip LOH clustering)

 

Paez JG, Lin M, Beroukhim R, Lee JC, Zhao X, Richter DJ, Gabriel S, Herman P, Sasaki H, Altshuler D, Li C, Meyerson M, Sellers WR (2004) Genome coverage and sequence fidelity of phi29 polymerase-based multiple strand displacement whole genome amplification. Nucleic Acids Research. 32(9):e71. (Abstract)

 

ZC Wang, M Lin, LJ Wei, C Li, A Miron, G Lodeiro, L Harris, S Ramaswamy, DM Tanenbaum, M Meyerson, JD Iglehart, A Richardson (2004) Loss of heterozygosity and its correlation with expression profiles in subclasses of invasive breast cancers. Cancer Research. 64(1): 64-71. (Abstract, Data)

 

RM Bachoo, RS Kim, KL Ligon, EA Maher, C Brennan, N Billings, S Chan, C Li, DH Rowitch, WH Wong and RA DePinho (2004) Molecular diversity of astrocytes with implications for neurological disorders. Proc. Natl. Acad. Sci. 101(22):8384-9. (Abstract, Joint first authors)

 

Munshi NC, Hideshima T, Carrasco D, Shammas M, Auclair D, Davies F, Mitsiades N, Mitsiades C, Kim RS, Li C, Rajkumar SV, Fonseca R, Bergsagel L, Chauhan D, Anderson KC (2004) Identification of genes modulated in multiple myeloma using genetically identical twin samples. Blood. 103(5):1799-806. (Abstract)

 

Ke Hao, Cheng Li, Carsten Rosenow, Wing H. Wong (2004) Detect and adjust for population stratification in population-based association study using genomic control markers: an application of Affymetrix Genechip Human Mapping 10K array

. European Journal of Human Genetics. 12:1001-1006. (Abstract, Highlight)

 

Ke Hao, Cheng Li, Carsten Rosenow, Wing Hung Wong (2004) Estimation of Genotype Error Rate Using Samples with Pedigree Information -- An application on GeneChip Mapping 10K array. Genomics. 84: 623-630. (Abstract)

 

Dring AM, Davies FE, Fenton JA, Roddam PL, Scott K, Gonzalez D, Rollinson S, Rawstron AC, Rees-Unwin KS, Li C, Munshi NC, Anderson KC, Morgan GJ (2004) A Global Expression-based Analysis of the Consequences of the t(4;14) Translocation in Myeloma. Clin Cancer Res. 10(17):5692-701. (PubMed)

 

DJ Willis, JA Kalish, C Li, ER Deutsch, MA Contreras, FW LoGerfo and WC Quist (2004) Temporal gene expression following prosthetic arterial grafting. Journal of Surgical Research. 120(1):27-36 (Abstract)

 

Kalish JA, Willis DJ, Li C, Link JJ, Deutsch ER, Contreras MA, Quist WC, Logerfo FW (2004) Temporal genomics of vein bypass grafting through oligonucleotide microarray analysis. Journal of Vascular Surgery. 39(3):645-54. (Abstract)

 

Zhou X, Li C, Mok SC, Chen Z, Wong DT (2004) Whole genome loss of heterozygosity profiling on oral squamous cell carcinoma by high-density single nucleotide polymorphic allele (SNP) array. Cancer Genet Cytogenet. 151(1):82-4.

 

Gentleman RC, Carey VJ, Bates DM, Bolstad B, Dettling M, Dudoit S, Ellis B, Gautier L, Ge Y, Gentry J, Hornik K, Hothorn T, Huber W, Iacus S, Irizarry R, Leisch F, Li C, Maechler M, Rossini AJ, Sawitzki G, Smith C, Smyth G, Tierney L, Yang JY, Zhang J (2004) Bioconductor: open software development for computational biology and bioinformatics. Genome Biol. 5(10):R80. (PubMed)

 

Zhong S, Tian L, Li C, Storch FK and Wong WH (2004) Comparative Analysis of Gene Sets in the Gene Ontology Space under the Multiple Hypothesis Testing Framework. Proc. IEEE Comp Systems Bioinformatics. 425-435. (Abstract, Software)

 

Hui Han, C. Lee Giles, Hongyuan Zha, Cheng Li, and Kostas Tsioutsiouliklis (2004) Two Supervised Learning Approaches for Name Disambiguation in Author Citations. Proceedings of ACM/IEEE Joint Conference on Digital Libraries (JCDL 2004). 296-305. (Abstract)

Shammas MA, Shmookler Reis RJ, Li C, Koley H, Hurley LH, Anderson KC, Munshi NC. (2004) Telomerase inhibition and cell growth arrest after telomestatin treatment in multiple myeloma. Clin Cancer Res. 10(2):770-6. (Abstract)

 

2003 (Top)

 

Cheng Li, George C. Tseng and Wing Hung Wong (2003) Model-based analysis of oligonucleotide arrays and issues in cDNA microarray analysis. In Statistical analysis of gene expression microarray data. Edited by Terry Speed. CRC Press. 1-34. (Amazon; consists of 3 previous papers: 1, 2, 3)

 

ME Lieberfarb, M Lin, M Lechpammer, C Li, DM Tanenbaum, PG Febbo, R L Wright, J Shim, PW Kantoff, M Loda, M Meyerson and WR Sellers (2003) Genome-wide Loss of Heterozygosity Analysis from Laser Capture Microdissected Prostate Cancer Using Single Nucleotide Polymorphic Allele (SNP) Arrays and a Novel Bioinformatics Platform dChipSNP. Cancer Research.  63(16): 4781-4785. (Abstract, Data and Software, joint first authors)

 

Chauhan D, Li G, Auclair D, Hideshima T, Richardson P, Podar K, Mitsiades N, Mitsiades C, Li C, Kim RS, Munshi N, Chen LB, Wong W, Anderson KC (2003) Identification of genes regulated by 2-methoxyestradiol (2ME2) in multiple myeloma cells using oligonucleotide arrays. Blood. 101(9):3606-14.

 

FE Davies, AM Dring, C Li, AC Rawstron, MA Shammas, SM O'Connor, JA Fenton, T Hideshima, D Chauhan, IT Tai, E Robinson, D Auclair, K Rees, D Gonzalez, AJ Ashcroft, R Dasgupta, C Mitsiades, N Mitsiades, LB Chen, WH Wong, NC Munshi, GJ Morgan and KC Anderson (2003) Insights into the multistep transformation of MGUS to myeloma using microarray expression analysis. Blood. 102(13):4504-11. (Abstract)

 

Schoenberg, F.P., Ferguson, T., and Li, C. (2003). Inverting Dirichlet tessellations. The Computer Journal 46(1), 76-83. (Abstract, C code)

2001 (Top)

 

Hakak Y, Walker JR, Li C, Wong WH, Davis KL, Buxbaum JD, Haroutunian V and Fienberg AA (2001) Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic schizophrenia. Proc. Natl. Acad. Sci. Vol. 98, 4746-4751. (Abstract; dChip Compare samples, Gene clustering and Sample classification by LDA)

 

Bhattacharjee A, Richards WG, Staunton J, Li C, Monti S, Vasa P, Ladd C, Beheshti J, Bueno R, Gillette M, Loda M, Weber G, Mark EJ, Lander ES, Wong W, Johnson BE, Golub TR, Sugarbaker DJ and Meyerson M (2001) Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses Proc. Natl. Acad. Sci. USA, Vol. 98, 13790-13795 (Abstract, Supplement, Data)

 

Eric E. Schadt, Cheng Li, Byron Ellis and Wing H. Wong (2001) Feature extraction and normalization algorithms for high-density oligonucleotide gene expression array data. Journal of Cellular Biochemistry. Supplement 37, 120-125. (Abstract)

 

Schoenberg, F., Berk, R., Fovell, R., Li, C., Lu, R., and Weiss, R. (2001). Approximation and inversion of a complex meteorological system via local linear filters. Journal of Applied Meteorology, 40(3), 446--458.

 

2000 (Top)

 

Irizarry K, Kustanovich V, Li C, Brown N, Nelson S, Wong W and Lee CJ (2000) Genome-wide analysis of single-nucleotide polymorphisms in human expressed sequences, Nature Genetics. Vol. 26, 233-236 (Abstract, database)

 

Eric E. Schadt, Cheng Li, Cheng Su, Wing H. Wong (2000) Analyzing high-density oligonucleotide gene expression array data, Journal of Cellular Biochemistry. 80, 192-202. (Abstract)